Article
Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese.
Pharmaceutical research - 1 Apr 1998
Yokoi T, Kamataki T
Abstract excerpt
Genetic polymorphism of drug metabolizing enzymes, particularly cytochrome P450(CYP), is an important cause of adverse drug reactions. Multiple gene mutations in CYP have been shown to be phenotype. The occurrence of genetic polymorphism has been seen in genes for CYP1A1, CYP2A6, CYP2C9, CYP2C19,...
Topics
- Aryl Hydrocarbon Hydroxylases
- Asian People
- Base Sequence
- Cytochrome P-450 CYP2A6
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Humans
- Japan
- Mixed Function Oxygenases
- Molecular Sequence Data
- Mutation
- Pharmaceutical Preparations
- Phenotype
- Polymorphism, Genetic