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Article

[Genetic polymorphisms in drug-metabolizing enzymes].

Nihon rinsho. Japanese journal of clinical medicine - 1 Jan 2002

Saruwatari Junji, Nakagawa Kazuko, Ishizaki Takashi

Abstract excerpt

Genetic polymorphisms in drug-metabolizing enzymes are responsible for interindividual differences in the disposition of numerous drugs. The poor metabolizers (PMs) are derived from mutant alleles of cytochrome P450 (CYP), and those PMs are more susceptible to the development of adverse drug reactions, when the parent drug is pharmacologically active, or are showing a lack of therapeutic efficacy, when a prodrug...

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PMID: 11808340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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