Cytochrome P450 in Pharmacogenetics: An Update.

doi:10.1016/bs.apha.2018.04.007

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Article

Cytochrome P450 in Pharmacogenetics: An Update.

Advances in pharmacology (San Diego, Calif.) - 1 Jan 2018

Tornio Aleksi, Backman Janne T

Abstract excerpt

Interindividual variability in drug disposition is a major cause of lack of efficacy and adverse effects of drug therapies. The majority of hepatically cleared drugs are metabolized by cytochrome P450 (CYP) enzymes, mainly in families CYP1, CYP2, and CYP3. Genes encoding these enzymes are highly variable with allele distribution showing considerable differences between populations. Genetic variability of...

Topics

Cytochrome P-450 Enzyme System
Genetic Variation
Humans
Multigene Family
Pharmacogenetics

Source

Open in PubMed

Identifiers

PMID: 29801580
DOI: 10.1016/bs.apha.2018.04.007

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