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Article

A mechanism of rifamycin inhibition and resistance in Pseudomonas aeruginosa.

The Journal of antimicrobial chemotherapy - 1 Jul 1996

Yee Y C, Kisslinger B, Yu V L, Jin D J

Abstract excerpt

We sought to study the nature of rifampicin resistance in Pseudomonas aeruginosa. We hypothesized that the rifamycin regions of RNA polymerase are conserved in P. aeruginosa and that rifampicin resistance is mediated by a mutation in the rpoB gene encoding the beta subunit of RNA polymerase. Transcription assays showed that 50 nM of rifampicin inhibited transcription > 99% in a clinical isolate (MIC = 32 mg/L)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8858465
DOI: 10.1093/jac/38.1.133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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A mechanism of rifamycin inhibition and resistance in Pseudomonas aeruginosa.PMID 8858465Read ↗

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Evaluating the activity of the RNA polymerase inhibitor myxopyronin B against Staphylococcus aureus.Semantic proximity Read ↗

Structural basis for the unexpected activity of rifamycin B against rifampicin-resistant RNA polymeraseSemantic proximity Read ↗

Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus.Semantic proximity Read ↗

Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.Semantic proximity Read ↗

Few amino acid positions in rpoB are associated with most of the rifampin resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Linking system-wide impacts of RNA polymerase mutations to the fitness cost of rifampin resistance in Pseudomonas aeruginosa.Semantic proximity Read ↗

RNA polymerase B subunit gene mutations in biofilm-embedded methicillin-resistant Staphylococcus aureus following rifampin treatment.Semantic proximity Read ↗

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