Article
Linking system-wide impacts of RNA polymerase mutations to the fitness cost of rifampin resistance in Pseudomonas aeruginosa.
mBio - 9 Dec 2014
Qi Qin, Preston Gail M, MacLean R Craig
Abstract excerpt
UNLABELLED: Fitness costs play a key role in the evolutionary dynamics of antibiotic resistance in bacteria by generating selection against resistance in the absence of antibiotics. Although the genetic basis of antibiotic resistance is well understood, the precise molecular mechanisms linking the genetic basis of resistance to its fitness cost remain poorly characterized. Here, we examine how the system-wide...
Topics
- Anti-Bacterial Agents
- DNA-Directed RNA Polymerases
- Drug Resistance, Bacterial
- Gene Expression Profiling
- Genes, Essential
- Mutation
- Pseudomonas aeruginosa
- Rifampin
- Transcription, Genetic