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Article

Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Oct 1998

Aubry-Damon H, Soussy C J, Courvalin P

Abstract excerpt

Mutations in the rifampin resistance-determining (Rif) regions of the rpoB gene of Staphylococcus aureus mutants obtained during therapy or in vitro were analyzed by gene amplification and sequencing. Each of the resistant clinical isolates, including five nonrelated clones and two strains isolated from the same patient, and of the 10 in vitro mutants had a single base pair change that resulted in an amino acid...

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Identifiers

PMID: 9756760
DOI: 10.1128/AAC.42.10.2590
PMCID: PMC105902

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