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Article

Inhibition of RNA Polymerase by Rifampicin and Rifamycin-Like Molecules

28 Apr 2020

Abstract excerpt

RNA polymerases (RNAPs) accomplish the first step of gene expression in all living organisms. However, the sequence divergence between bacterial and human RNAPs makes the bacterial RNAP a promising target for antibiotic development. The most clinically important and extensively studied class of antibiotics known to inhibit bacterial RNAP are the rifamycins. For example, rifamycins are a vital element of the...

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PMID: 32342856
DOI: 10.1128/ecosalplus.esp-0017-2019

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