Article

Structural basis for the unexpected activity of rifamycin B against rifampicin-resistant RNA polymerase

2026-07-14

Abstract excerpt

<h4>Summary</h4> Rifamycins inhibit bacterial transcription by targeting RNA polymerase (RNAP), but their clinical effectiveness is limited by the rapid emergence of resistance caused by mutations within the rifamycin-binding pocket. Rifamycin B (Rif B), one of the earliest discovered members of this antibiotic family and a precursor of clinically used derivatives, has remained poorly characterized because of its...

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Literature Corpus work: 0de4d5f7-6285-5696-a552-2c52f57e874f
DOI: 10.64898/2026.07.13.738162

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