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Article

Mutations in RNA polymerase that drive the emergence of antibiotic resistance.

Current opinion in microbiology - 1 Aug 2026

Patel Yesha, Helmann John D

Abstract excerpt

RNA polymerase (RNAP) catalyzes transcription, the first step of gene expression. In bacteria, numerous regulatory proteins and signaling molecules fine-tune RNAP activity in a promoter-specific manner. The resultant changes in gene expression allow cells to acclimate to an ever-changing environment. In addition to phenotypic adaptation, increases in cell fitness can also result from changes in the genome. Here,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42330662
DOI: 10.1016/j.mib.2026.102783
PMCID: PMC13288759

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