Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluating the activity of the RNA polymerase inhibitor myxopyronin B against Staphylococcus aureus.

FEMS microbiology letters - 1 Jun 2011

Moy Terence I, Daniel Anu, Hardy Crystal, Jackson Andrew, Rehrauer Owen, Hwang You Seok, Zou Dong, Nguyen Kien, Silverman Jared A, Li Qingyi, Murphy Christopher

Abstract excerpt

Myxopyronin B (MyxB) binds to the switch region of RNA polymerase (RNAP) and inhibits transcriptional initiation. To evaluate the potential development of MyxB as a novel class of antibiotic, we characterized the antimicrobial activity of MyxB against Staphylococcus aureus. Spontaneous MyxB resistance in S. aureus occurred at a frequency of 8 × 10(-8) , similar to that of rifampin. The MyxB-resistant mutants were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Evaluation, Preclinical

Share to Enzyme Inhibitors

Share to Lactones

Share to Microbial Sensitivity Tests

Share to Staphylococcal Infections

Share to Staphylococcus aureus

Source

Identifiers

PMID: 21477256
DOI: 10.1111/j.1574-6968.2011.02282.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluating the activity of the RNA polymerase inhibitor myxopyronin B against Staphylococcus aureus.PMID 21477256Read ↗

Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae.Semantic proximity Read ↗

Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase.Semantic proximity Read ↗

Frequency, spectrum, and nonzero fitness costs of resistance to myxopyronin in Staphylococcus aureus.Semantic proximity Read ↗

Inhibition of RNA Polymerase by Rifampicin and Rifamycin-Like MoleculesSemantic proximity Read ↗

Constrained RNA polymerase mutational pathways distinguish corallopyronin A resistance from rifampicin resistance in staphylococci.Semantic proximity Read ↗

A Synthetic Antibiotic Scaffold Effective Against Multidrug-Resistant Bacterial PathogensSemantic proximity Read ↗

Synthetic macrolides overcoming MLSBK-resistant pathogensSemantic proximity Read ↗

Mutations in RNA polymerase that drive the emergence of antibiotic resistance.Semantic proximity Read ↗

Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus.Semantic proximity Read ↗

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.Semantic proximity Read ↗

Antibiotics GE23077, Novel Inhibitors of Bacterial RNA Polymerase I. Taxonomy, Isolation and CharacterizationSemantic proximity Read ↗

JMM profile: rifampicin: a broad-spectrum antibioticSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.