Article
Resistance to rifampicin: a review.
The Journal of antibiotics - 1 Sept 2014
Goldstein Beth P
Abstract excerpt
Resistance to rifampicin (RIF) is a broad subject covering not just the mechanism of clinical resistance, nearly always due to a genetic change in the β subunit of bacterial RNA polymerase (RNAP), but also how studies of resistant polymerases have helped us understand the structure of the enzyme, the intricacies of the transcription process and its role in complex physiological pathways. This review can only...
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