Rifampin: mechanisms of action and resistance.

Abstract excerpt

Rifampin specifically inhibits bacterial RNA polymerase, the enzyme responsible for DNA transcription, by forming a stable drug-enzyme complex with a binding constant of 10(-9) M at 37 C. The corresponding mammalian enzymes are not affected by rifampin. Bacterial resistance to rifampin is caused...

Topics

• DNA-Directed RNA Polymerases
• Drug Resistance, Microbial
• Escherichia coli
• Klebsiella
• Mutation
• Rifampin
• Staphylococcus aureus