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Article

Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.

Genes & development - 1 Apr 1996

Hofmann F, Livingston D M

Abstract excerpt

The cyclin-dependent kinases cdk2 and cdk3 are required for the G1-S transition in mammalian cells. Here we show that G1 arrest induced by the corresponding dominant-negative mutants of these enzymes, cdk2dn or cdk3dn, is resistant to the action of SV40 T antigen (T). In the presence of cdk2dn, T released active E2F from negative control by pRb and its related family members (pocket proteins) but failed to induce...

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PMID: 8846921
DOI: 10.1101/gad.10.7.851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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