Article
Distinct roles for cyclin-dependent kinases in cell cycle control.
Science (New York, N.Y.) - 24 Dec 1993
van den Heuvel S, Harlow E
Abstract excerpt
The key cell-cycle regulator Cdc2 belongs to a family of cyclin-dependent kinases in higher eukaryotes. Dominant-negative mutations were used to address the requirement for kinases of this family in progression through the human cell cycle. A dominant-negative Cdc2 mutant arrested cells at the G2 to M phase transition, whereas mutants of the cyclin-dependent kinases Cdk2 and Cdk3 caused a G1 block. The mutant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.