Article
Distinct roles for cyclin-dependent kinases in cell cycle control.
Science (New York, N.Y.) - 24 Dec 1993
van den Heuvel S, Harlow E
Abstract excerpt
The key cell-cycle regulator Cdc2 belongs to a family of cyclin-dependent kinases in higher eukaryotes. Dominant-negative mutations were used to address the requirement for kinases of this family in progression through the human cell cycle. A dominant-negative Cdc2 mutant arrested cells at the G2...
Topics
- Amino Acid Sequence
- CDC2 Protein Kinase
- CDC2-CDC28 Kinases
- Cell Cycle
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinases
- Cyclins
- Genetic Vectors
- Humans
- Molecular Sequence Data
- Mutation
- Plasmids
- Protein Kinases
- Protein Serine-Threonine Kinases
- Tumor Cells, Cultured