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Article

Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation.

Developmental cell - 1 May 2006

Berthet Cyril, Klarmann Kimberly D, Hilton Mary Beth, Suh Hyung Chan, Keller Jonathan R, Kiyokawa Hiroaki, Kaldis Philipp

Abstract excerpt

Mouse knockouts of Cdk2 and Cdk4 have demonstrated that, individually, these genes are not essential for viability. To investigate whether there is functional redundancy, we have generated double knockout (DKO) mice. Cdk2-/- Cdk4-/- DKOs die during embryogenesis around E15 as a result of heart defects. We observed a gradual decrease of Retinoblastoma protein (Rb) phosphorylation and reduced expression of...

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Identifiers

PMID: 16678773
DOI: 10.1016/j.devcel.2006.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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