Article
Cyclin E-induced S phase without activation of the pRb/E2F pathway.
Genes & development - 1 Jun 1997
Lukas J, Herzinger T, Hansen K, Moroni M C, Resnitzky D, Helin K, Reed S I, Bartek J
Abstract excerpt
In cells of higher eukaryotes, cyclin D-dependent kinases Cdk4 and Cdk6 and, possibly, cyclin E-dependent Cdk2 positively regulate the G1- to S-phase transition, by phosphorylating the retinoblastoma protein (pRb), thereby releasing E2F transcription factors that control S-phase genes. Here we pe...
Topics
- Animals
- Carrier Proteins
- Cell Cycle Proteins
- Cells, Cultured
- Cyclin D1
- Cyclins
- DNA-Binding Proteins
- E2F Transcription Factors
- Fibroblasts
- G1 Phase
- Genes, Reporter
- Humans
- Interphase
- Luciferases
- Mice
- Microinjections
- Mutation
- Oncogene Proteins