Article
Unmasking the redundancy between Cdk1 and Cdk2 at G2 phase in human cancer cell lines.
Cell cycle (Georgetown, Tex.) - 1 May 2006
L'Italien Lawrence, Tanudji Marcel, Russell Loren, Schebye Xiao Min
Abstract excerpt
A series of studies published in 2003 has challenged the essentiality of Cdk2. A recently published work indicates that cyclin E-Cdk1 compensates for Cdk2's function at G1/S transition in Cdk2(-/-) Mefs. In this study, we uncovered a redundant mechanism between Cdk1 and Cdk2 at G2 in multiple cancer cell lines. When either Cdk2 or Cdk1 is ablated using RNAi, there were complex shifts of cyclin A towards its...
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