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Article

Cdk2 Is Required for p53-Independent G2/M Checkpoint Control

26 Feb 2010

Abstract excerpt

The activation of phase-specific cyclin-dependent kinases (Cdks) is associated with ordered cell cycle transitions. Among the mammalian Cdks, only Cdk1 is essential for somatic cell proliferation. Cdk1 can apparently substitute for Cdk2, Cdk4, and Cdk6, which are individually dispensable in mice. It is unclear if all functions of non-essential Cdks are fully redundant with Cdk1. Using a genetic approach, we show...

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PMID: 20195506
DOI: 10.1371/journal.pgen.1000863

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