Quantitative differences between cyclin-dependent kinases underlie the unique functions of CDK1 in human cells

Abstract excerpt

One of the most intriguing features of cell-cycle control is that, although there are multiple cyclin-dependent kinases (CDKs) in higher eukaryotes, a single CDK is responsible for both G 1 -S and G 2 -M in yeasts. By leveraging a rapid conditional silencing system in human cell lines, we confirm that CDK1 assumes the role of G 1 -S CDK in the absence of CDK2. Unexpectedly, CDK1 deficiency does not prevent...

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