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Article

S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human cells.

Molecular and cellular biology - 1 Apr 2001

Hu B, Mitra J, van den Heuvel S, Enders G H

Abstract excerpt

Cyclin-dependent kinase 2 (Cdk2) is essential for initiation of DNA synthesis in higher eukaryotes. Biochemical studies in Xenopus egg extracts and microinjection studies in human cells have suggested an additional function for Cdk2 in activation of Cdk1 and entry into mitosis. To further examine the role of Cdk2 in human cells, we generated stable clones with inducible expression of wild-type and...

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Identifiers

PMID: 11283255
DOI: 10.1128/MCB.21.8.2755-2766.2001
PMCID: PMC86906

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Source receipt: pubmed, retrieved 7 Sept 2026.

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