Article
Inhibition of c-ras reactivates thyroglobulin synthesis in middle-T transformed thyroid cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1995
Di Jeso B, Feliciello A, Pacifico F, Iannelli A, D'Armiento F, Liguoro D, Giuliano P, Ferulano G, Avvedimento E V
Abstract excerpt
Differentiated thyroid cells expressing polyoma Middle-T became transformed and tumorigenic when injected into syngenic animals. The expression of thyroglobulin was greatly reduced and no longer responsive to thyrotropin (TSH) and to cAMP. Inhibition of endogenous c-ras by the expression of two t...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Cell Differentiation
- Cell Line, Transformed
- Cell Transformation, Viral
- Cyclic AMP
- Genes, ras
- Iodine
- Mutation
- RNA, Messenger
- Rats
- Receptors, Thyrotropin
- Signal Transduction
- Thyroglobulin
- Thyroid Gland
- Thyrotropin
- ras Proteins