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Article

Inhibition of c-ras reactivates thyroglobulin synthesis in middle-T transformed thyroid cells.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1995

Di Jeso B, Feliciello A, Pacifico F, Iannelli A, D'Armiento F, Liguoro D, Giuliano P, Ferulano G, Avvedimento E V

Abstract excerpt

Differentiated thyroid cells expressing polyoma Middle-T became transformed and tumorigenic when injected into syngenic animals. The expression of thyroglobulin was greatly reduced and no longer responsive to thyrotropin (TSH) and to cAMP. Inhibition of endogenous c-ras by the expression of two transdominant negative mutant H-ras genes, Asn17 and Leu61-Ser186, reactivated thyroglobulin synthesis. Reactivation of...

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PMID: 8845309

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Inhibition of c-ras reactivates thyroglobulin synthesis in middle-T transformed thyroid cells.PMID 8845309Read ↗

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