Article
Expression of mutationally activated G alpha s stimulates growth and differentiation of thyroid FRTL5 cells.
Oncogene - 1 Dec 1994
Muca C, Vallar L
Abstract excerpt
The alpha subunit of the GTP-binding protein Gs mediates hormonal stimulation of adenylyl cyclase. Human pituitary and thyroid tumours harbour mutations of G alpha s that constitutively activate the protein by inhibiting its intrinsic GTPase activity. We have investigated the mitogenic action of mutationally activated alpha s in thyroid FRTL5 cells, a cell line dependent upon thyroid-stimulating hormone (TSH) for...
Topics
- 1-Methyl-3-isobutylxanthine
- Cell Differentiation
- Cell Division
- Cells, Cultured
- GTP-Binding Proteins
- Guanine Nucleotides
- Humans
- Mutation
- Thyroid Gland
- Thyrotropin