Article
Human N-ras, TRK-T1, and RET/PTC3 oncogenes, driven by a thyroglobulin promoter, differently affect the expression of differentiation markers and the proliferation of thyroid epithelial cells.
Oncology research - 1 Jan 1999
Portella G, Vitagliano D, Borselli C, Melillo R M, Salvatore D, Rothstein J L, Vecchio G, Fusco A, Santoro M
Abstract excerpt
The ras family members and the tyrosine kinases RET and TRK are frequently activated in human tumors of the thyroid gland. To ascertain the effects of these oncogenes in cultured thyroid cells we have generated expression vectors containing activated versions of the three genes under the control of the thyroid-specific thyroglobulin gene promoter. Here we show that the expression of the three oncogenes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.