Article
Mutated human Kirsten ras, driven by a thyroglobulin promoter, induces a growth advantage and partially dedifferentiates rat thyroid epithelial cells in vitro.
International journal of cancer - 27 Nov 1995
Monaco C, Califano D, Chiappetta G, Mineo A, De Franciscis V, Vecchio G, Santelli G
Abstract excerpt
We have earlier shown that expression of the human activated Ki-ras, directed by the rat thyroglobulin (TG) promoter in the thyroid gland of transgenic mice, is able to induce thyroid benign tumors, albeit at low incidence. A likely explantation of our results is that the low levels of exogenous...
Topics
- Amino Acid Sequence
- Animals
- Cell Differentiation
- Cell Division
- Cell Transformation, Neoplastic
- Epithelial Cells
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutation
- Plasmids
- Promoter Regions, Genetic
- Rats
- Rats, Inbred F344
- Thyroglobulin