Article
Conditional expression of RET/PTC induces a weak oncogenic drive in thyroid PCCL3 cells and inhibits thyrotropin action at multiple levels.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 2003
Wang Jianwei, Knauf Jeffrey A, Basu Saswata, Puxeddu Efisio, Kuroda Hiroaki, Santoro Massimo, Fusco Alfredo, Fagin James A
Abstract excerpt
Chromosomal rearrangements linking the promoter(s) and N-terminal domain of unrelated gene(s) to the C terminus of RET result in constitutively activated chimeric forms of the receptor in thyroid cells (RET/PTC). RET/PTC rearrangements are thought to be tumor-initiating events; however, the early biological consequences of RET/PTC activation are unknown. To explore this, we generated clonal lines derived from...
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