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Article

Restored expression of transforming growth factor beta type II receptor in k-ras-transformed thyroid cells, TGF beta-resistant, reverts their malignant phenotype.

Journal of cellular physiology - 1 Aug 1997

Coppa A, Mincione G, Lazzereschi D, Ranieri A, Turco A, Lucignano B, Scarpa S, Ragano-Caracciolo M, Colletta G

Abstract excerpt

Transforming growth factor beta 1 (TGF beta 1) inhibits the growth of normal rat epithelial thyroid cells (FRTL-5 strain) by counteracting thyrotropin (TSH)-stimulated DNA synthesis and by slowing the cells in the G1 phase of the cell cycle. Here, we have studied two clones of FRTL-5 thyroid cell line transformed by the wild type (wt) v-k-ras oncogene (K.M.A1, K.M.A2) and one clone (A6) transformed by a...

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Identifiers

PMID: 9258341
DOI: 10.1002/(SICI)1097-4652(199708)172:2<200::AID-JCP7>3.0.CO;2-S

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Source receipt: pubmed, retrieved 7 Sept 2026.

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