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Article

Restored expression of transforming growth factor beta type II receptor in k-ras-transformed thyroid cells, TGF beta-resistant, reverts their malignant phenotype.

Journal of cellular physiology - 1 Aug 1997

Coppa A, Mincione G, Lazzereschi D, Ranieri A, Turco A, Lucignano B, Scarpa S, Ragano-Caracciolo M, Colletta G

Abstract excerpt

Transforming growth factor beta 1 (TGF beta 1) inhibits the growth of normal rat epithelial thyroid cells (FRTL-5 strain) by counteracting thyrotropin (TSH)-stimulated DNA synthesis and by slowing the cells in the G1 phase of the cell cycle. Here, we have studied two clones of FRTL-5 thyroid cell...

Topics

Animals
Carrier Proteins
Cell Division
Cell Transformation, Neoplastic
Cells, Cultured
Drug Resistance
Genes, ras
Phenotype
RNA, Messenger
Rats
Receptors, Transforming Growth Factor beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thyroid Gland

Transfection

Transforming Growth Factor beta

Source

Identifiers

PMID: 9258341
DOI: 10.1002/(SICI)1097-4652(199708)172:2<200::AID-JCP7>3.0.CO;2-S

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9258341-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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