Article
Oncogenic potential of a mutant human thyrotropin receptor expressed in FRTL-5 cells.
Oncogene - 26 Feb 1998
Fournes B, Monier R, Michiels F, Milgrom E, Misrahi M, Feunteun J
Abstract excerpt
An abnormal stimulation of the cAMP pathway has been recognized as the primary event in various pathological situations that lead to goitrogenesis or thyroid tumors. Thyroid adenomas are monoclonal neoplasms that become independent of thyroid stimulating hormone (TSH) in their secretory function...
Topics
- Animals
- Cattle
- Cell Adhesion
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Cricetinae
- Cricetulus
- Cyclic AMP
- Humans
- Mice
- Mice, Nude
- Mutation
- Phenotype
- Polymerase Chain Reaction
- Rats
- Receptors, Thyrotropin
- Thymus Gland