Article
Thyroid cell transformation requires the expression of the HMGA1 proteins.
Oncogene - 2 May 2002
Berlingieri Maria Teresa, Pierantoni Giovanna M, Giancotti Vincenzo, Santoro Massimo, Fusco Alfredo
Abstract excerpt
Elevated expression of HMGA1 and HMGA2 proteins is correlated with a highly malignant phenotype in several human tumors. We previously demonstrated that the block of HMGA2 protein synthesis prevented rat thyroid cell transformation by murine retroviruses. Suppression of HMGA2 synthesis was associated with lack of induction of HMGA1 proteins suggesting that both HMGA1 and HMGA2 play a role in the process of...
Topics
- Animals
- Cell Line, Transformed
- Cell Transformation, Viral
- Cells, Cultured
- DNA, Antisense
- DNA, Complementary
- Genes, ras
- HMGA1a Protein
- HMGA2 Protein
- Kirsten murine sarcoma virus
- Mice
- Mice, Nude
- Oncogene Protein p21(ras)
- Phenotype
- Rats
- Rats, Inbred F344
- Recombinant Fusion Proteins
- Species Specificity