Article
Contrasting effects of activating mutations of GalphaS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells.
Oncogene - 26 Aug 1999
Ludgate M, Gire V, Crisp M, Ajjan R, Weetman A, Ivan M, Wynford-Thomas D
Abstract excerpt
The cyclic AMP pathway is a major regulator of thyrocyte function and proliferation and, predictably, its inappropriate activation is associated with a sub-set of human thyroid tumours. Activating mutations are, however, more common in the thyrotropin receptor (TSHR) than in its downstream transducer, Galphas. To investigate whether this reflects an inherent difference in their oncogenic potency, we compared the...
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