Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RhoA activation promotes transformation and loss of thyroid cell differentiation interfering with thyroid transcription factor-1 activity.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 2002

Medina Diego L, Rivas Marcos, Cruz Patricia, Barroso Isabel, Regadera Javier, Santisteban Pilar

Abstract excerpt

Highly specialized cells, the thyrocytes, express a thyroid-specific set of genes for thyroglobulin (Tg), thyroperoxidase, and the transcription factors TTF-1, TTF-2, and Pax-8. The implication of the small GTPase RhoA in TSH-mediated proliferation of FRTL-5 rat thyroid cells has been previously demonstrated. To further analyze RhoA function in thyroid cell proliferation and differentiation patterns, we combined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenicity Tests
Share to Proto-Oncogene Proteins c-fos

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-jun

Share to rhoA GTP-Binding Protein

Share to Thyroglobulin

Share to Thyroid Gland

Share to Thyroid Nuclear Factor 1

Share to Thyrotropin

Source

Identifiers

PMID: 11773437
DOI: 10.1210/mend.16.1.0749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RhoA activation promotes transformation and loss of thyroid cell differentiation interfering with thyroid transcription factor-1 activity.PMID 11773437Read ↗

Human N-ras, TRK-T1, and RET/PTC3 oncogenes, driven by a thyroglobulin promoter, differently affect the expression of differentiation markers and the proliferation of thyroid epithelial cells.Semantic proximity Read ↗

Mutated human Kirsten ras, driven by a thyroglobulin promoter, induces a growth advantage and partially dedifferentiates rat thyroid epithelial cells in vitro.Semantic proximity Read ↗

Characterization of a thyroid hormone-mediated short-loop feedback control of TSH receptor gene in an anaplastic human thyroid cancer cell line.Semantic proximity Read ↗

Ha-ras interference with thyroid cell differentiation is associated with a down-regulation of thyroid transcription factor-1 phosphorylation.Semantic proximity Read ↗

Oncogenic potential of a mutant human thyrotropin receptor expressed in FRTL-5 cells.Semantic proximity Read ↗

Inhibition of c-ras reactivates thyroglobulin synthesis in middle-T transformed thyroid cells.Semantic proximity Read ↗

Expression of mutationally activated G alpha s stimulates growth and differentiation of thyroid FRTL5 cells.Semantic proximity Read ↗

Dissociation of thyrotropin receptor function and thyrotropin dependency in rat thyroid tumour cell lines derived from FRTL-5.Semantic proximity Read ↗

Partial transformation of human thyroid epithelial cells by mutant Ha-ras oncogene.Semantic proximity Read ↗

Comparative proteomic analysis to dissect differences in signal transduction in activating TSH receptor mutations in the thyroid.Semantic proximity Read ↗

Stepwise transformation of primary thyroid epithelial cells by a mutant Ha-ras oncogene: an in vitro model of tumor progression.Semantic proximity Read ↗

Contrasting effects of activating mutations of GalphaS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.