Article
The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1993
Santoro M, Melillo R M, Grieco M, Berlingieri M T, Vecchio G, Fusco A
Abstract excerpt
We have recently reported that about 50% of papillary thyroid carcinomas harbor an activated TRK or RET oncogene. Two retroviral vectors containing the activated TRK or RET/PTC oncogene have been used to infect a differentiated rat thyroid epithelial cell line, namely the PC Clone 3 cell line. Up...
Topics
- Animals
- Cell Division
- Cell Line, Transformed
- Epithelium
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Oncogenes
- Phenotype
- Protein-Tyrosine Kinases
- Rats
- Rats, Inbred F344
- Thyroid Gland