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Article

Plaque formation in brain transplants exposed to human beta-amyloid precursor protein 695.

Acta neuropathologica - 1 Aug 1996

Bayer T A, Fossgreen A, Czech C, Beyreuther K, Wiestler O D

Abstract excerpt

Abnormal processing of beta-amyloid precursor protein (APP) and precipitation of amyloidogenic beta A4 peptide have been implicated in the pathogenesis of Alzheimer's disease (AD). In an attempt to generate an in vivo model of APP-associated pathology, we have introduced recombinant retroviral vectors harboring normal and mutant cDNAs for human neuron-specific APP 695 into fetal rat brain transplants. A minor...

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Source

Identifiers

PMID: 8841658
DOI: 10.1007/s004010050500

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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