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Article

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice.

Acta neuropathologica - 1 May 2014

Umeda Tomohiro, Maekawa Satomi, Kimura Tetsuya, Takashima Akihiko, Tomiyama Takami, Mori Hiroshi

Abstract excerpt

Senile plaques comprised of Aβ aggregates and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau filaments are the hallmarks of Alzheimer's disease (AD). A number of amyloid precursor protein (APP) transgenic (Tg) mice harboring APP mutations have been generated as animal models of AD. These mice successfully display amyloid plaque formation and subsequent tau hyperphosphorylation, but seldom...

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Identifiers

PMID: 24531886
DOI: 10.1007/s00401-014-1259-1

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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