Article
Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.
The EMBO journal - 16 Oct 1995
De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K, Dotti C G
Abstract excerpt
A distinguishing feature of Alzheimer's disease (AD) is the deposition of amyloid plaques in brain parenchyma. These plaques arise by the abnormal accumulation of beta A4, a proteolytic fragment of amyloid precursor protein (APP). Despite the fact that neurons are dramatically affected in the cou...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid
- Amyloid beta-Peptides
- Animals
- Cell Polarity
- Cells, Cultured
- Fluorescent Antibody Technique
- Genetic Vectors
- Hippocampus
- Humans
- Molecular Sequence Data
- Mutation
- Neurons