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Article

Memory-related deficits following selective hippocampal expression of Swedish mutation amyloid precursor protein in the rat.

Experimental neurology - 1 Aug 2006

Gong Yan, Meyer Edwin M, Meyers Craig A, Klein Ronald L, King Michael A, Hughes Jeffrey A

Abstract excerpt

The gene encoding for the Swedish double mutation (K595N/M596L) of amyloid precursor protein (APP695Swe) was expressed bilaterally in adult rat hippocampus to determine its long-term effects on memory-related behavior as well as amyloid deposition. Recombinant adeno-associated viral serotype 2 (rAAV2) vectors were injected that contained either non-expressing DNA or cDNA encoding for APP695Swe under control of a...

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Identifiers

PMID: 16780838
DOI: 10.1016/j.expneurol.2006.02.136

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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