Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant and native human beta-amyloid precursor proteins in transgenic mouse brain.

Neurobiology of aging - 1 Jan 2000

Howland D S, Savage M J, Huntress F A, Wallace R E, Schwartz D A, Loh T, Melloni R H, DeGennaro L J, Greenberg B D, Siman R

Abstract excerpt

Human beta-amyloid precursor protein (beta APP) has been targeted to transgenic neurons using synapsin I promoter-based chimeric transgenes. Native human beta APP was introduced as well as beta APP containing mutations genetically linked to familial Alzheimer's disease (AD) and to hereditary cerebral hemorrhage with amyloidosis-Dutch type. In mouse brain, human beta APP RNA was up to 60% as abundant as total...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Immunoblotting
Share to In Situ Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutation

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 8544921
DOI: 10.1016/0197-4580(95)00078-s

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant and native human beta-amyloid precursor proteins in transgenic mouse brain.PMID 8544921Read ↗

Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence.Semantic proximity Read ↗

Expression of Transgenic APP mRNA Is the Key Determinant for Beta-Amyloid Deposition in PS2APP Transgenic MiceSemantic proximity Read ↗

Formation of beta-amyloid protein deposits in brains of transgenic mice.Semantic proximity Read ↗

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice.Semantic proximity Read ↗

Levels and Alternative Splicing of Amyloid β Protein Precursor (APP) Transcripts in Brains of APP Transgenic Mice and Humans with Alzheimer's DiseaseSemantic proximity Read ↗

Alterations in beta-amyloid production and deposition in brain regions of two transgenic models.Semantic proximity Read ↗

Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels.Semantic proximity Read ↗

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.Semantic proximity Read ↗

Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.Semantic proximity Read ↗

Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice.Semantic proximity Read ↗

Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice.Semantic proximity Read ↗

circAβ RNA drives the formation and deposition of β-amyloid plaques in the sporadic Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.