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Article

A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition.

Neurobiology of aging - 1 Jul 2009

Flood Dorothy G, Lin Yin-Guo, Lang Diane M, Trusko Stephen P, Hirsch James D, Savage Mary J, Scott Richard W, Howland David S

Abstract excerpt

Many transgenic mouse models of Alzheimer's disease (AD) that deposit amyloid (Abeta) have been produced, but development of an Abeta-depositing rat model has not been successful. Here, we describe a rat model with extracellular fibrillar Abeta deposition. Two lines of Sprague Dawley rats with transgenes expressing human amyloid precursor protein (APP) with the familial AD (FAD) mutations K670N/M671L and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18053619
DOI: 10.1016/j.neurobiolaging.2007.10.006

Genes

APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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