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Article

Immunohistochemical detection of the delayed formation of nonfibrillar large amyloid-β aggregates.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Feb 2016

Ochiishi Tomoyo, Itakura Akira, Liu Lei, Akatsu Hiroyasu, Kohno Hideki, Nishimura Masaki, Yoshimune Kazuaki

Abstract excerpt

The occurrence of senile plaques consisting of amyloid-β protein (Aβ) is a major neuropathological hallmark of Alzheimer's disease (AD). We previously developed and characterized monoclonal antibodies 31-2 and 75-2 that specifically bind to nonfibrillar Aβ1-42 aggregates with diameters of more than 220 and 50 nm, respectively. Here, we report the use of these antibodies to examine the aggregation of exogenous...

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Identifiers

PMID: 26805741
DOI: 10.1111/gtc.12332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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