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Article

Brain environment and Alzheimer's disease mutations affect the survival, migration and differentiation of neural progenitor cells.

Current Alzheimer research - 1 Nov 2012

Karkkainen Virve, Magga Johanna, Koistinaho Jari, Malm Tarja

Abstract excerpt

Enhancement of neurogenesis and stem cell transplantation are potential therapies for neurodegenerative diseases. In Alzheimer's disease (AD) newborn neural cells and the transplanted cells encounter a diseased brain where the accumulation of toxic amyloid-β (Aβ) peptides disturbs normal functions and interactions of brain cells. In addition, ADlinked mutatations in newborn neurons or autologously transplanted...

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Identifiers

PMID: 22950909
DOI: 10.2174/156720512803569028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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