Article
Proteolytical processing of mutated human amyloid precursor protein in transgenic mice.
Brain research. Molecular brain research - 1 Jul 1997
Czech C, Delaère P, Macq A F, Reibaud M, Dreisler S, Touchet N, Schombert B, Mazadier M, Mercken L, Theisen M, Pradier L, Octave J N, Beyreuther K, Tremp G
Abstract excerpt
The evidence that betaA4 is central to the pathology of Alzheimer's disease (AD) came from the identification of several missense mutations in the amyloid precursor protein (APP) gene co-segregating with familial AD (FAD). In an attempt to study the proteolytical processing of mutated human APP in vivo, we have created transgenic mice expressing the human APP695 isoform with four FAD-linked mutations. Expression...
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