Article
A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation.
Biochemical and biophysical research communications - 6 Jul 2007
Folkesson Ronnie, Malkiewicz Katarzyna, Kloskowska Ewa, Nilsson Tatjana, Popova Elena, Bogdanovic Nenad, Ganten Ursula, Ganten Detlev, Bader Michael, Winblad Bengt, Benedikz Eirikur
Abstract excerpt
In recent years, transgenic mice have become valuable tools for studying mechanisms of Alzheimer's disease (AD). With the aim of developing an animal model better for memory and neurobehavioural testing, we have generated a transgenic rat model of AD. These animals express human amyloid precursor protein (APP) containing the Swedish AD mutation. The highest level of expression in the brain is found in the cortex,...
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