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Article

2-Hydroxyadenine (isoguanine) as oxidative DNA damage: its formation and mutation inducibility.

Nucleic acids symposium series - 1 Jan 1995

Kamiya H, Kasai H

Abstract excerpt

In our experiments we found that hydroxylation occurs at the C-2 position of adenine by oxygen radical treatment (Fe(2+)-EDTA) of dA, dATP, and single- and double-stranded DNA. This oxidatively damaged base, 2-hydroxyadenine (also known as isoguanine), was produced more efficiently in monomers than in polynucleotides. 2-Hydroxydeoxyadenosine triphosphate was incorporated opposite T and C in a DNA template by DNA...

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PMID: 8841637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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2-Hydroxyadenine (isoguanine) as oxidative DNA damage: its formation and mutation inducibility.PMID 8841637Read ↗

[Molecular mechanisms of mutations induced by DNA lesions].Semantic proximity Read ↗

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Mutagenic potentials of damaged nucleic acids produced by reactive oxygen/nitrogen species: approaches using synthetic oligonucleotides and nucleotides: survey and summary.Semantic proximity Read ↗

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.Semantic proximity Read ↗

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues.Semantic proximity Read ↗

2-Hydroxy-dATP is incorporated opposite G by Escherichia coli DNA polymerase III resulting in high mutagenicity.Semantic proximity Read ↗

2-Hydroxy-2'-deoxyadenosine 5'-triphosphate enhances A.T --> C.G mutations caused by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate by suppressing its degradation upon replication in a HeLa extract.Semantic proximity Read ↗

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