Article
2-Hydroxyadenine (isoguanine) as oxidative DNA damage: its formation and mutation inducibility.
Nucleic acids symposium series - 1 Jan 1995
Kamiya H, Kasai H
Abstract excerpt
In our experiments we found that hydroxylation occurs at the C-2 position of adenine by oxygen radical treatment (Fe(2+)-EDTA) of dA, dATP, and single- and double-stranded DNA. This oxidatively damaged base, 2-hydroxyadenine (also known as isoguanine), was produced more efficiently in monomers th...
Topics
- Base Sequence
- DNA
- DNA Damage
- DNA-Directed DNA Polymerase
- Guanine
- Hydroxylation
- Molecular Structure
- Mutation
- Reactive Oxygen Species