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Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta.

DNA repair - 1 Mar 2008

Hidaka Katsuhiko, Yamada Masami, Kamiya Hiroyuki, Masutani Chikahide, Harashima Hideyoshi, Hanaoka Fumio, Nohmi Takehiko

Abstract excerpt

Aberrant oxidation is a property of many tumor cells. Oxidation of DNA precursors, i.e., deoxynucleotide triphosphates (dNTPs), as well as DNA is a major cause of genome instability. Here, we report that human DNA polymerase eta (h Poleta) incorporates oxidized dNTPs, i.e., 2-hydroxy-2'-deoxyadenosine 5'-triphosphate (2-OH-dATP) and 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (8-OH-dGTP), into DNA in an erroneous...

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PMID: 18242151
DOI: 10.1016/j.dnarep.2007.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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