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Mutations induced by 2-hydroxy-dATP during in vitro replication with a HeLa extract.

Nucleic acids research. Supplement (2001) - 1 Jan 2003

Satou Kazuya, Harashima Hideyoshi, Kamiya Hiroyuki

Abstract excerpt

The mutagenicity of oxidized dATP, 2-hydroxydeoxyadenosine 5'-triphosphate (2-OH-dATP), was examined using an SV40 origin-dependent in vitro replication system with a HeLa extract. 2-OH-dATP mainly elicited a G x C to A x T transition, and a G x C to T x A transversion to a lesser extent. Interestingly, the mutagenicity of 2-OH-dATP was enhanced in the presence of 2-hydroxydeoxyadenosine 5'-diphosphate, an...

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PMID: 14510512
DOI: 10.1093/nass/3.1.325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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