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8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1 Jan 1992

Abstract excerpt

Mutations caused by oxidative DNA damage may contribute to human disease. A major product of that damage is 8-hydroxyguanine (oh8Gua). Because of differences in experimental design, the base pairing specificity of oh8G in vivo is not completely resolved. Here, oh8dGTP and DNA polymerase were used in two complementary bacteriophage plaque color assays to examine the mutagenic specificity of oh8Gua in vivo. The...

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PMID: 1730583
DOI: 10.1016/s0021-9258(18)48474-8

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