Article
UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides.
DNA repair - 1 Dec 2007
Hori Mika, Ishiguro Chieko, Suzuki Tetsuya, Nakagawa Noriko, Nunoshiba Tatsuo, Kuramitsu Seiki, Yamamoto Kazuo, Kasai Hiroshi, Harashima Hideyoshi, Kamiya Hiroyuki
Abstract excerpt
Oxidatively damaged DNA precursors (deoxyribonucleotides) are formed by reactive oxygen species. After the damaged DNA precursors are incorporated into DNA, they might be removed by DNA repair enzymes. In this study, to examine whether a nucleotide excision repair enzyme, Escherichia coli UvrABC, could suppress the mutations induced by oxidized deoxyribonucleotides in vivo, oxidized DNA precursors,...
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