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Article

2-Hydroxy-dATP is incorporated opposite G by Escherichia coli DNA polymerase III resulting in high mutagenicity.

Nucleic acids research - 1 Apr 2000

Kamiya H, Kasai H

Abstract excerpt

Four kinds of oxidatively damaged DNA precursors, 8-hydroxydeoxyguanosine 5'-triphosphate (8-OH-dGTP), 2-hydroxydeoxyadenosine 5'-triphosphate (2-OH-dATP), 5-hydroxydeoxycytidine 5'-triphosphate (5-OH-dCTP) and 5-formyldeoxyuridine 5'-triphosphate (5-CHO-dUTP), were employed in in vitro gap-filling reactions of the supF gene conducted by the Escherichia coli DNA polymerase III holoenzyme, and these treated DNAs...

Topics

Adenosine Triphosphate
Base Pairing
Base Sequence
DNA Damage
DNA Polymerase III
DNA Repair
DNA, Bacterial
Deoxyguanine Nucleotides
Escherichia coli
Genes, Bacterial
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oxidation-Reduction

Source

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Identifiers

PMID: 10710431
DOI: 10.1093/nar/28.7.1640
PMCID: PMC102799

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2-Hydroxy-dATP is incorporated opposite G by Escherichia coli DNA polymerase III resulting in high mutagenicity.PMID 10710431Read ↗

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