Article
ADP-ribosylation of p53 tumor suppressor protein: mutant but not wild-type p53 is modified.
Journal of cellular biochemistry - 1 Jul 1996
Wesierska-Gadek J, Bugajska-Schretter A, Cerni C
Abstract excerpt
Poly(ADP-ribosyl)ation of mutant and wild-type p53 was studied in transformed and nontransformed rat cell lines constitutively expressing the temperature-sensitive p53135val. It was found that in both cell types at 37.5 degrees C, where overexpressed p53 exhibits mutant conformation and cytoplasmic localization, a considerable part of the protein was poly(ADP-ribosyl)ated. Using densitometric scanning, the...
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