Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Binding of cellular proteins to a conformational domain of tumor suppressor protein p53.

Oncogene - 1 Dec 1993

Maxwell S A, Roth J A

Abstract excerpt

The genes regulated by p53, as well as the factors modulating its function, need to be identified before the mechanism of action of p53 in control of cell growth can be adequately understood. Binding of the SV40 large T-antigen protein to an evolutionally conserved (conformational) domain of p53 inhibits p53's DNA-binding and transcription activation activities. Cellular proteins might also bind to this same...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Protein Binding
Share to Protein Conformation
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Division

Share to Lung Neoplasms

Share to Mutation

Share to Proteins

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 8247546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Binding of cellular proteins to a conformational domain of tumor suppressor protein p53.PMID 8247546Read ↗

Sequence-specific interaction of a conformational domain of p53 with DNA.Semantic proximity Read ↗

Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system.Semantic proximity Read ↗

Posttranslational regulation of p53 tumor suppressor protein function.Semantic proximity Read ↗

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.Semantic proximity Read ↗

Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.Semantic proximity Read ↗

Partially transformed T3T3 cells express high levels of mutant p53 in the 'wild-type' immunoreactive form with defective oligomerization.Semantic proximity Read ↗

p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress.Semantic proximity Read ↗

Two cellular proteins that bind to wild-type but not mutant p53.Semantic proximity Read ↗

Distinct regions of p53 have a differential role in transcriptional activation and repression functions.Semantic proximity Read ↗

Mutant p53 proteins bind DNA abnormally in vitro.Semantic proximity Read ↗

Sensitive immunodetection of pseudo-mutant conformation of p53 protein in human cells using immune complex with protein A conjugates.Semantic proximity Read ↗

Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.