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Article

Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus.

Oncogene - 6 Jan 2000

Rubbi C P, Milner J

Abstract excerpt

The p53 tumour suppressor functions as a sensor of genotoxic stress and, once activated, induces cell growth arrest or apoptosis. The precise intranuclear localization of latent p53 protein in non-stressed cells is unknown. Such information is essential in order to understand how relatively few molecules of p53 can detect and respond to DNA damage. Here we present the first detailed supramolecular localization of...

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Identifiers

PMID: 10644983
DOI: 10.1038/sj.onc.1203378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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